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1.
Anal Biochem ; 685: 115404, 2024 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-37993043

RESUMO

In the category of 2D materials, MoS2 a transition metal dichalcogenide, is a novel and intriguing class of materials with interesting physicochemical properties, explored in applications ranging from cutting-edge optoelectronic to the frontiers of biomedical and biotechnology. MoS2 nanostructures an alternative to heavy toxic metals exhibit biocompatibility, low toxicity and high stability, and high binding affinity to biomolecules. MoS2 nanostructures provide a lot of opportunities for the advancement of novel biosensing, nanodrug delivery system, electrochemical detection, bioimaging, and photothermal therapy. Much efforts have been made in recent years to improve their physiochemical properties by developing a better synthesis approach, surface functionalization, and biocompatibility for their safe use in the advancement of biomedical applications. The understanding of parameters involved during the development of nanostructures for their safe utilization in biomedical applications has been discussed. Computational studies are included in this article to understand better the properties of MoS2 and the mechanism involved in their interaction with biomolecules. As a result, we anticipate that this combined experimental and computational studies of MoS2 will inspire the development of nanostructures with smart drug delivery systems, and add value to the understanding of two-dimensional smart nano-carriers.


Assuntos
Nanoestruturas , Elementos de Transição , Molibdênio/química , Nanoestruturas/química , Sistemas de Liberação de Medicamentos
2.
Ther Deliv ; 14(4): 311-329, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-37403985

RESUMO

This review explores the potential of photonic nanoparticles for cancer theranostics. Photonic nanoparticles offer unique properties and photonics capabilities that make them promising materials for cancer treatment, particularly in the presence of near-infrared light. However, the size of the particles is crucial to their absorption of near-infrared light and therapeutic potential. The limitations and challenges associated with the clinical use of photonic nanoparticles, such as toxicity, immune system clearance, and targeted delivery to the tumor are also discussed. Researchers are investigating strategies such as surface modification, biodegradable nanoparticles, and targeting strategies to improve biocompatibility and accumulation in the tumor. Ongoing research suggests that photonic nanoparticles have potential for cancer theranostics, further investigation and development are necessary for clinical use.


Tiny particles called 'photonic nanoparticles' can be used to help treat cancer. These particles have special properties that allow them to be used with special light to treat cancer. However, the size of the particles is really important, so scientists are trying to find ways to make sure they are the right size. There are also some challenges with using these particles in people, like making sure they don't harm the body and that they go to the right place. Scientists are working on ways to improve the safety of these particles and make sure they go where they need to.


Assuntos
Nanopartículas Metálicas , Nanopartículas , Neoplasias , Humanos , Medicina de Precisão , Óptica e Fotônica , Nanomedicina Teranóstica , Neoplasias/diagnóstico , Neoplasias/tratamento farmacológico
3.
J Drug Target ; 27(8): 813-829, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30601068

RESUMO

Nanoparticles have several exciting applications nowadays almost in every area. Biomedical field is one of them where nanoparticles show potential for various applications due to their exceptional and exciting properties. The presence of heavy metals in inorganic nanoparticles lead to toxicity in the biological system, therefore, their direct use for drug delivery is restricted. But encapsulating their surface with a non-toxic or biocompatible material makes them a promising material for application in drug delivery system. This review highlights the various characteristics and factors involved in nano-drug delivery system. The understanding of various mechanisms involved during the uptake of nanoparticles by cells, toxicity, surface chemistry and several drug release mechanisms has been discussed. This article also includes various computational studies used to optimise the design and properties of drug delivery system.


Assuntos
Nanopartículas/química , Preparações Farmacêuticas/química , Animais , Materiais Biocompatíveis/química , Sistemas de Liberação de Medicamentos/métodos , Humanos , Nanotecnologia/métodos
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